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Charlie Hunnam was originally cast in the lead role alongside Léa Seydoux but dropped out due to scheduling conflicts and was replaced by Ewan McGregor.
When Cole is preparing to operate on Zoe, he turns to Ash and inquires, "Proprioception?" Proprioception is what enables a person to close their eyes and touch their nose with their index finger.
"Jewels: You'd be surprised how many men come to me and don't want anything physical. Some just talk. Some just want forgiveness. What I've learned about men is that sometimes they don't really desire you. They desire the way you make them feel. Zoe: But they... they know you're not real. Jewels: The Designer only cares that we're real enough to make money."
"[first lines] Female Computer Voice: Describe the last person you were in a relationship with. Zoe: He was a loner. He... Not an obvious choice. He needed to let himself be loved. We tried. It failed. Female Computer Voice: If your dog was ill and had to have its front legs removed to survive, would you have the surgery or have the dog put down? Zoe: I would have the surgery. Female Computer Voice: What are the things that would attract you to a potential partner? Zoe: The things he loves. The things he wants to be. [smiling now] Zoe: Whether he likes pancakes or French toast. Female Computer Voice: Would you help someone you love end their life if that was their choice? Zoe: Umm..."
